KLOW

In the vial

The name

KLOW is a nickname, not a trademark. Nobody owns it and no two suppliers are obliged to put the same thing in the vial. That is why the ratio on this page is described as what we found agreement on, rather than as the specification.

Also sold or searched as

• KLOW 80
• K-LOW
• klow peptideo

The 4 peptides in it

• GHK-Cu →Glycyl-L-histidyl-L-lysine copper(II)

  A tripeptide — glycine, histidine, lysine — bound to a copper(II) ion. The copper is why a reconstituted vial turns blue, and why anything containing GHK-Cu should be kept out of the light. It occurs naturally in human plasma, saliva and urine.

• KPV →α-MSH (11-13), Lys-Pro-Val

  The three C-terminal residues of α-melanocyte-stimulating hormone — lysine, proline, valine. The K in KLOW is this peptide. It is supplied as a trifluoroacetate salt, so the labelled mass and the peptide mass are not the same number.

• BPC-157 →Body Protection Compound 157

  A synthetic pentadecapeptide — fifteen amino acids — derived from a sequence found in human gastric juice protein. It is not an approved medicine anywhere, and it is on the WADA prohibited list.

• TB-500 →Thymosin β4 fragment (Ac-LKKTETQ)

  A seven-amino-acid fragment of thymosin β4, acetylated at the N-terminus. TB-500 is not a separate molecule from thymosin β4 — it is a short active region of it. Thymosin β4 itself is a 43-residue protein identified in 1990 as the main intracellular G-actin-sequestering peptide in most vertebrate cells.

What a blend means

All 4 peptides were freeze-dried together in one vial, so they dissolve into one liquid. You cannot draw one without drawing all of them. Every draw comes out at the ratio the vial was filled at.

Set the GHK-Cu in a draw to 1 mg and the same draw carries 200 mcg of KPV, 200 mcg of BPC-157 and 200 mcg of TB-500. Want more of one? You take more of the others too.

Mixing it

Looking for how much to take? Why nobody can source a KLOW dose

Handling

Refrigerate at 2–8°C and protect from light.

We could not find a sourced shelf life for a mixed KLOW vial in a normal fridge, so we don't print one. Why that number is missing

What we could not source

Every number on this site says where it came from. These are the ones we went looking for and could not find. Each one ends with what we do about it. Admitting you do not know something and then carrying on regardless is not admitting anything.

1. How much KPV will actually dissolve in water

   The best we found is "Sparingly soluble: 1–10 mg/mL" in PBS (pH 7.2). That is a rough band, not a measured number, and it is not in water.

   What we do So we never work out the water for KLOW. You tell the calculator how much water you added, and it tells you which line on the syringe to draw to.

2. A maker's spec sheet for the KLOW ratio

   There is no maker. The split on this page is what several independent community sources all said, and the numbers add up. But no label anywhere backs it.

   What we do So we show you the exact ratio we used, and you can change the vial total. If your vial says something different, the numbers on this site are not about your vial.

3. How long a mixed vial keeps in a normal fridge

   Suppliers publish storage conditions for powder in a −20 °C freezer, not for liquid at 2–8 °C in a kitchen. The 28 days everyone repeats comes from pharmacy convention, not from any study of these peptides.

   What we do So we print no use-by date and no countdown, anywhere on the site or in anything you download.

4. The most liquid that should go under the skin in one go

   The figures people quote come from clinical guidance written for completely different drugs. Nothing we found is specific to these compounds.

   What we do So the calculator never refuses a draw for being too big. It tells you the volume and flags it as large, and you decide.

5. How much liquid a KLOW vial actually holds

   These vials turn up unbranded and unlabelled. The minimum and maximum water figures we use are our own working guesses, not something anyone measured.

   What we do So when our answer goes over that guess, we say so. Read that warning as a nudge to look at your own vial, not as a fact about it.

What the research studied

1. Mendias CL, Awan TM2026Sports MedicineGHK-Cu · BPC-157 · TB-500

   Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance

   Reviews the pharmacology, safety profile and regulatory status of twelve peptides sold direct to patients — BPC-157, GHK-Cu and TB-500 among them. Describes the market in unapproved compounds as operating largely outside regulatory oversight.

   PMID 41966639 →
2. Vasireddi N, Hahamyan H, Salata MJ, et al.2025HSS JournalBPC-157

   Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review

   Systematic review of the BPC-157 literature published up to 3 June 2024, drawn from PubMed, Cochrane and Embase, covering mechanism, metabolism and safety. States that BPC-157 has no FDA approval and is banned in professional sport.

   PMID 40756949 →
3. Seiwerth S, Milavic M, Vukojevic J, et al.2021Frontiers in PharmacologyBPC-157

   Stable Gastric Pentadecapeptide BPC 157 and Wound Healing

   Reviews BPC-157 across skin wound models — incisional and excisional wounds, deep burns, diabetic ulcers and alkali burns — and notes the peptide had previously been used in ulcerative colitis and multiple sclerosis trials.

   PMID 34267654 →
4. Siméon A, Wegrowski Y, Bontemps Y, Maquart FX2000Journal of Investigative DermatologyGHK-Cu

   Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu(2+)

   Rat experimental wound model plus rat dermal fibroblast cultures. Repeated 2 mg injections of GHK-Cu raised wound-tissue dry weight and total protein, and increased type I collagen and glycosaminoglycan production.

   PMID 11121126 →
5. Hannappel E2007Annals of the New York Academy of SciencesTB-500

   beta-Thymosins

   Traces what thymosin beta-4 actually is. Identified in 1990 as the main intracellular G-actin-sequestering peptide in most vertebrate cells. TB-500 is a fragment of this protein, not a separate molecule.

   PMID 17468232 →
6. Xiao B, Xu Z, Viennois E, et al.2017Molecular TherapyKPV

   Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

   Loaded KPV into hyaluronic-acid-functionalised polymeric nanoparticles and delivered it orally in a colitis model. KPV is a naturally occurring tripeptide — lysine, proline, valine.

   PMID 28143741 →